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Why Injectable Instead of Oral

doi: 10.1016/j.envint.2024.108859 34 FrazierT

[2] Use of estradiol cypionate injection is contraindicated in individuals with undiagnosed abnormal vaginal bleeding, known or suspected breast cancer or other estrogen-dependent neoplasia, active or prior venous thromboembolism, recent arterial thrombo-occlusive disease such as stroke or myocardial infarction, severe hepatic impairment, a history of hypersensitivity to estradiol or any excipients, and in those who are or may become pregnant

That distinction matters for long-term sleep quality, morning alertness, and the overnight recovery processes (GH release, tissue repair, immune function) that depend on genuine deep sleep