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The brain tissue of PD patients is typically characterized by the death of dopaminergic, neuromelanin-containing neurons in the area of locus coeruleus and substantia nigra
Further, oxidative damage to phospholipids can induce ferroptosis, as described earlier, which has now been directly linked to the induction of neuroinflammation (Cao Y et al., 2021
Tonelli C, Chio IIC, Tuveson DA
Younger individuals typically respond faster, though older users still report benefits
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